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A Different rhGH |
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A Better rhGH
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A Different rhGH |
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Some people treat Jintropin™ AQ as reconstituted Jintropin, it is
totally wrong. Actually, Jintropin™ AQ is liquid formulation growth
hormone, same as Lilly's Humatrope Pen and Genentech's Nutropin
, which is kept at liquid formulation during all the
manufacturing process. Therefore the hGH in AQ are all in its
natural active form, never being damaged by freeze-drying
lyophilization process, which is known to damage hGH potency (please
note that in all hGH instructions, they tell you never freeze your
hGH, that's why).
Jintropin™ AQ differs from Jintropin powder in many aspects; here
we would like to show you the key differences, hope it can give you
a better understanding of Jintropin™ AQ and its advantages comparing
normal powder form Jintropin and all the other lyophilized powder
growth hormone.
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Avoid lyophilization
process, higher potency |
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More convenient:
ready to inject, no need for reconstitution. |
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More accurate: pen
injection device. |
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Less antibody
formation, better for long term use. |
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A Better rhGH |
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Higher Biological Activity |
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Jintropin™ AQ¨s biological activity is higher than
normal powder form of rhGH. |
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The potency of Jintropin AQ was tested
against normal powder form of hGH by rat body weight gain
assay. It clearly tells that the rats receiving AQ gains more
weight in 1-2 weeks than normal powder form of hGH.
The
following animal experiment is designed to research Jintrpin
AQ's activity in promoting growth in hypophysectomized rats,
which is the classical way of testing hGH potency published in
USP.
Group 1 is positive control group (The rats in
this group have an operation, but their pituitary gland are
untouched);
Group 2 is model group (The rats in this
group have an operation and their pituitary gland were cut).
They were injected daily with same normal saline.
Group
3 is Jintropin™ AQ group with daily injection of Jintropin™
AQ;
Group 4 is Generic hGH powder group with daily
injection of Generic hGH powder. After 14 days, we measure the
weight and height of the rats.
The results are showing
below: |
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Obviously, you can find that the rats in
Group 3: Jintropin™ AQ group gains more weight and height than
group 2 and group 4. Their tails are also longer. |
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Conclusion
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| Comparing to normal powder rhGH, Jintropin™
AQ has higher biological activity. Its activity to promote the
growth of hypophysectomized rat is most
potent. | |
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Lower Antibody
Formation |
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Jintropin™ AQ has better
clinical effect and lower antibody formation. |
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Normal lyophilized powder rhGH, because it contains
trace amount of rhGH aggregates, would always generate slight amount
of rhGH antibodies in small percentage of people (about 1-2% of the
people). Antibodies to rhGH will compromise the long term benefit of
rhGH.Beware of antibodies to hGH. However, Jintropin™ AQ doesn't cause any
formation of antibodies because it contains absolutely no rhGH
aggregates.
Comparison of rates of developing antibodies
between Jintropin™ AQ, Jintropin and other Chinese hGH: |
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Reference:
(1)Qin Shuwen, Shi Yifan,
Wang Defen, et al. A prospective study of therapeutic effect of
recombinant human growth hormone in idiopathic growth hormone
deficient children before adolescence. Chin J Endocrinol Metab,
February 1999, Vol 15, No. 1.
(2)Pan Huiru,Chen Jiqing, Zhang
lina, et al. Effect of treatment of growth hormone deficiency
with domestic recombinant human growth hormone. J Appl Clin
Pediatr, September 2001,Vol. 16 No.5.
(3)Yu Yerong, Pan Huiru,
Wang Defen, et al. Clinical research of treatment of growth
hormone deficiency with domestic recombinant human growth
hormone. Chin J Endocrinol Metab, April 1999, Vol 15,
No.2. |
| Conclusion |
| In Jintropin™ AQ group, there is no
antibody formation at all. |
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